The purpose of present study was to compare Kyron T-314 with other superdisintegrants and optimize the fast dissolving tablet of carbamazepine using 32 full factorial design. The amounts of disintegrant (X1) and type of disintegrant (X2) were selected as independent variables and disintegration time(DT), wetting time(WT), and time required for 80% drug release (T80%) were selected as a dependent variable. Carbamazepine fast dissolving tablets were prepared by direct compression method using different disintegrants in different amount. Microcrystalline Cellulose (MCC) used as directly compressible binder to increase the compressibility and flow of the ingredients. The tablets of all batches were evaluated for different parameters. Regression analysis and response surface analysis were performed for dependent variables. The prepared tablets were characterized by FTIR for drug excipient compatibility Studies. The optimized formulation was introduced for short term stability study. All formulation (B1-B9) had disintegration time from 20 to 40 sec and wetting time from 63 to 89 sec with sufficient mechanical strength. It was observed that amounts of disintegrant and type of disintegrant had significant influence on DT, WT and T80% (P<0.05). Formulation B3 was selected as an optimum formulation as it shows less disintegration time (20 sec) as compared to other formulation. It was concluded that Kyron T-314 is suitable for preparation of fast dissolving tablets.
Loading....